Police say the road is closed between Sinnington and Keldholme
North Yorkshire Polcie say they are currently dealing with "a serious RTC" on the A170 between Sinnington and Keldholme.
The A170 was closed just after 3:30pm on Thursday and is expected to be closed for some time.
Officers say:
"Motorists travelling between Pickering and Kirkbymoorside should find an alternative route."
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Two Yorkshire Coast towns have been named among the most popular destinations in the United Kingdom for a festive staycation this year.
Elite cyclists will tackle a gruelling route along the East Yorkshire coast and through the Wolds as Stage 3 of the Tour of Britain takes place on Friday.
Preparations are under way to manage the potential economic fallout for coastal businesses if a proposed overnight visitor levy is introduced in North Yorkshire.
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