The US military says it has struck a boat "engaged in narco-trafficking operations", killing three men.
The vessel "was transiting along known narco-trafficking routes in the Eastern Pacific and was engaged in narco-trafficking operations", the US Southern Command said on X.
The military has not provided evidence that the boat or the men on board were involved in drug trafficking.
Footage of the strike on Friday shows the small boat floating in the Pacific before an explosion, causing it to burst into flames.
President Donald Trump previously said the US is in "armed conflict" with cartels in Latin America.
US strikes on alleged drug boats have killed at least 148 people in at least 43 attacks in the Caribbean Sea and eastern Pacific Ocean since September, including 11 people earlier this week.
Read more from Sky News:
Trump announces global tariff
Trump's trade war is not over
Mr Trump has justified the attacks as a necessary escalation to stem the flow of drugs.
But critics have questioned the legality and effectiveness of the strikes, as the fentanyl behind many fatal overdoses is smuggled into the US via land from Mexico, where it is produced with chemicals imported from China and India.
In January, the US launched a direct military attack on Venezuela, extraditing Nicolas Maduro and his wife Cilia Flores, transporting them both to New York to face narcoterrorism and other charges, which both deny.
(c) Sky News 2026: Three men killed in US strike on alleged drug boat
Trump announces global tariff after Supreme Court rebuke
Over 1,000 councillors sign Palestine solidarity pledge amid claims of 'political opportunism'
Charles Bronson pledges to 'expose unlawful sentence' ahead of parole hearing
Bishop of Lincoln arrested on suspicion of sexual assault
How Iran might be preparing itself for a potential US strike
'I'd have headaches. I felt sick, emotional': Inside the lab tackling the head trauma imbalance in women's rugby
Court approves law requiring Louisiana schools to display Ten Commandments
Abbey Road is opening its doors for a rave: 'There's something about this place - hopefully we don't ruin it'
