The road will be closed from 8pm on Friday to 6am on Monday.
Traffic will be diverted via Pickering using the A169 and A170 when the works at Rillington close the A64 this weekend.
Overnight lane closures have been in place for a couple of weeks as footway, drainage and kerbing work has been carried out.
This weekend National Highways say they will be completing resurfacing, associated road marking and road stud renewal work which will require a full closure of the road between High Street and West Knapton.
The road will be closed from Friday 8 October at 8pm until Monday 11 October at 6am.
Traffic will be diverted via Pickering using the A169 and A170.
Access to properties directly on the A64 will be maintained and residents will be sent a letter giving more detailed information about the arrangements for this.
There will be no access to or from the A64 at the junctions of Sands Lane and Pine Tree Avenue. Clearly signed diversions will be in place.
National Highways Project Manager Richard Burgess said:
“We will make the most of the traffic management required for the resurfacing to also repair the footway and kerbing in four locations and carry out sections of drainage maintenance. Doing this work together reduces the need for additional road closures in the area.
“We’d like to thank road users and residents for their patience as this important work progresses.”
A second weekend closure planned for the same times next weekend (Friday 15 to Monday 18 October) has been postponed. A new date will be arranged after October half term.


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